Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

@article{Sato2008ResolutionOL,
  title={Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone},
  author={Yasushi Sato and Kazuyuki Murase and Junji Kato and Masayoshi Kobune and Tsutomu Sato and Yutaka Kawano and Rishu Takimoto and Kouichi Takada and Koji Miyanishi and Takuya Matsunaga and Tetsuji Takayama and Yoshiro Niitsu},
  journal={Nature Biotechnology},
  year={2008},
  volume={26},
  pages={431-442}
}
There are currently no approved antifibrotic therapies for liver cirrhosis. We used vitamin A–coupled liposomes to deliver small interfering RNA (siRNA) against gp46, the rat homolog of human heat shock protein 47, to hepatic stellate cells. Our approach exploits the key roles of these cells in both fibrogenesis as well as uptake and storage of vitamin A. Five treatments with the siRNA-bearing vitamin A–coupled liposomes almost completely resolved liver fibrosis and prolonged survival in rats… CONTINUE READING
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