Resolution of inflammation: the beginning programs the end

@article{Serhan2005ResolutionOI,
  title={Resolution of inflammation: the beginning programs the end},
  author={Charles Nicholas Serhan and John Savill},
  journal={Nature Immunology},
  year={2005},
  volume={6},
  pages={1191-1197}
}
Acute inflammation normally resolves by mechanisms that have remained somewhat elusive. Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins. After entering tissues, granulocytes promote the switch of arachidonic acid–derived prostaglandins and leukotrienes to lipoxins, which initiate the termination sequence. Neutrophil recruitment thus ceases and programmed death by apoptosis is engaged. These… Expand
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1
2
3
4
5
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References

SHOWING 1-10 OF 105 REFERENCES
Apoptosis in resolution of inflammation
  • J. Savill
  • Biology, Medicine
  • Journal of leukocyte biology
  • 1997
TLDR
A growing understanding of the mechanisms regulating leukocyte apoptosis and of the molecules mediating safe phagocytic clearance of dying cells may yield new insights into the pathogenesis and therapy of inflammatory diseases. Expand
Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.
TLDR
Changes in the senescent neutrophil that are associated with their recognition by macrophages are the subject of this investigation, and these processes may represent a mechanism for the removal of neutrophils during inflammation that also serves to limit the degree of tissue injury. Expand
Lipid mediator class switching during acute inflammation: signals in resolution
TLDR
Results indicate that first-phase eicosanoids promote a shift to anti-inflammatory lipids: functionally distinct lipid-mediator profiles switch during acute exudates to “reprogram” the exudate PMNs to promote resolution. Expand
Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators
TLDR
Inhibition of apoptosis of aging neutrophil populations was associated with prolongation of the functional life span of the population as assessed by the ability of neutrophils to spread on glass surfaces, to polarize in response to deliberate stimulation with N‐formyl‐Met‐Leu‐Phe, and to release the granule enzyme marker myeloperoxidase on fMLP stimulation. Expand
Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins1
TLDR
The first molecular resolution circuits and their major components activated by specific novel lipid mediators (i.e., resolvin E1 and 10,17S-docosatriene) to promote resolution are characterized. Expand
Points of control in inflammation
TLDR
The non-inflammatory state does not arise passively from an absence of inflammatory stimuli; rather, maintenance of health requires the positive actions of specific gene products to suppress reactions to potentially inflammatory stimuli that do not warrant a full response. Expand
Anti-inflammatory lipid mediators and insights into the resolution of inflammation
TLDR
This review focuses on this emerging area of inflammation research and describes the mediators and mechanisms that are currently stealing the headlines. Expand
Cyclooxygenase 2 Plays a Pivotal Role in the Resolution of Acute Lung Injury1
TLDR
Findings indicate a protective role in ALI for COX-2-derived mediators, in part via enhanced lipoxin signaling, and carry potential therapeutic implications for this devastating clinical disorder. Expand
IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation
TLDR
A new role for IKKα is described in the negative regulation of macrophage activation and inflammation, and the two IKK catalytic subunits have evolved opposing but complimentary roles needed for the intricate control of inflammation and innate immunity. Expand
Initial cytokine exposure determines function of macrophages and renders them unresponsive to other cytokines.
TLDR
The functional response of BMDMs to complex mixtures of cytokines was determined by the first cytokine to which they were exposed, which has obvious implications for Mphi function in vivo. Expand
...
1
2
3
4
5
...