Resolution of inflammation: the beginning programs the end

  title={Resolution of inflammation: the beginning programs the end},
  author={Charles N Serhan and John Savill},
  journal={Nature Immunology},
Acute inflammation normally resolves by mechanisms that have remained somewhat elusive. Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins. After entering tissues, granulocytes promote the switch of arachidonic acid–derived prostaglandins and leukotrienes to lipoxins, which initiate the termination sequence. Neutrophil recruitment thus ceases and programmed death by apoptosis is engaged. These… CONTINUE READING
Highly Influential
This paper has highly influenced 37 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
746 Citations
89 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 746 extracted citations


Publications referenced by this paper.
Showing 1-10 of 89 references

Molecular circuits of resolution: Formation and actions of REV IEW

  • Bannenberg, G.L
  • J. Immunol
  • 2005

Resolvin E1, a novel endogenous lipid mediator derived from omega3 eicosapentaenoic acid, protects against TNBS-induced colitis

  • M Arita
  • Proc. Natl. Acad. Sci. USA 102,
  • 2005

Similar Papers

Loading similar papers…