Resolution of inflammation: the beginning programs the end

  title={Resolution of inflammation: the beginning programs the end},
  author={Charles Nicholas Serhan and John Savill},
  journal={Nature Immunology},
Acute inflammation normally resolves by mechanisms that have remained somewhat elusive. Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins. After entering tissues, granulocytes promote the switch of arachidonic acid–derived prostaglandins and leukotrienes to lipoxins, which initiate the termination sequence. Neutrophil recruitment thus ceases and programmed death by apoptosis is engaged. These… 

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  • C. Serhan
  • Chemistry
    The American journal of pathology
  • 2010
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  • J. Savill
  • Biology, Medicine
    Journal of leukocyte biology
  • 1997
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