Resolution of inflammation: the beginning programs the end

@article{Serhan2005ResolutionOI,
  title={Resolution of inflammation: the beginning programs the end},
  author={Charles N Serhan and John Savill},
  journal={Nature Immunology},
  year={2005},
  volume={6},
  pages={1191-1197}
}
Acute inflammation normally resolves by mechanisms that have remained somewhat elusive. Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins. After entering tissues, granulocytes promote the switch of arachidonic acid–derived prostaglandins and leukotrienes to lipoxins, which initiate the termination sequence. Neutrophil recruitment thus ceases and programmed death by apoptosis is engaged. These… CONTINUE READING
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