Resolution of infection promotes a state of dormancy and long survival of CD4 memory T cells

@inproceedings{Dalai2011ResolutionOI,
  title={Resolution of infection promotes a state of dormancy and long survival of CD4 memory T cells},
  author={Sarat Kumar Dalai and Stanislav Khoruzhenko and Charles G. Drake and Chunfa C. Jie and Scheherazade Sadegh-Nasseri},
  booktitle={Immunology and cell biology},
  year={2011}
}
Memory T cells survive throughout the lifetime of an individual and are protective upon recall. It is not clear how memory T cells can live so long. Here, we demonstrate that at the resolution of a viral infection, low levels of antigen are captured by B cells and presented to specific CD4(+) memory T cells to render a state of unresponsiveness. We demonstrate in two systems that this process occurs naturally during the fall of antigen and is associated with a global gene expression program… CONTINUE READING
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