Resolution of chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography using methylated beta-cyclodextrins.

@article{ukowski1988ResolutionOC,
  title={Resolution of chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography using methylated beta-cyclodextrins.},
  author={J. Żukowski and D. Sybilska and J. Bojarşki and J. Szejtli},
  journal={Journal of chromatography},
  year={1988},
  volume={436 3},
  pages={
          381-90
        }
}
The correlation between the capacity factors of enantiomers of chiral barbiturates and the concentrations of beta-cyclodextrin, heptakis(2,6-di-O-methyl)-beta-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin dissolved in the mobile phase was studied using LiChrosorb RP-18 as the stationary phase. Owing to the very strong adsorption of permethylated beta-cyclodextrin on the ODS surface a chiral stationary phase is generated dynamically and forms complexes with the solutes; this… Expand
35 Citations
Direct enantiomeric separations by high performance liquid chromatography using cyclodextrins.
  • S. M. Han
  • Chemistry, Medicine
  • Biomedical chromatography : BMC
  • 1997
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