Resolution of cAMP signals in three-dimensional microdomains using novel, real-time sensors.

  title={Resolution of cAMP signals in three-dimensional microdomains using novel, real-time sensors.},
  author={Jeffrey W. Karpen and Thomas C. Rich},
  journal={Proceedings of the Western Pharmacology Society},
A large number of hormones, neurotransmitters, and odorants alter cellular behavior by triggering changes in intracellular levels of cAMP. Although the effector proteins that bind cAMP have been identified, it is not known how this one messenger can differentially regulate the activities of hundreds of cellular proteins. The spatial and temporal nature of cAMP signals and, thus, their information content remain largely unknown. We present here a high-resolution method for measuring cAMP signals… CONTINUE READING


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