Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes.

@article{Haslett1992ResolutionOA,
  title={Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes.},
  author={Christopher Haslett},
  journal={Clinical science},
  year={1992},
  volume={83 6},
  pages={639-48}
}
We have identified a pathway for granulocyte removal in tissues which is controlled by apoptosis. This process can be modulated by agents in the inflammatory microenvironment and leads to loss of neutrophil secretory function and its phagocytosis by macrophages which utilize a novel recognition mechanism such that the macrophage does not release pro-inflammatory mediators. It is hypothesized that this represents an alternative fate to necrosis, and one which would tend to limit tissue injury… CONTINUE READING