Resolution of Recombination Intermediates: Mechanisms and Regulation.

  title={Resolution of Recombination Intermediates: Mechanisms and Regulation.},
  author={Stephen C West and Miguel G Blanco and Ying Wai Chan and Jo{\~a}o Matos and Shriparna Sarbajna and Haley D. M. Wyatt},
  journal={Cold Spring Harbor symposia on quantitative biology},
DNA strand break repair by homologous recombination leads to the formation of intermediates in which sister chromatids are covalently linked. The efficient processing of these joint molecules, which often contain four-way structures known as Holliday junctions, is necessary for efficient chromosome segregation during mitotic division. Because persistent chromosome bridges pose a threat to genome stability, cells ensure the complete elimination of joint molecules through three independent… CONTINUE READING
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