Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice.

@article{Stephens2002ResolutionOP,
  title={Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice.},
  author={Richard H Stephens and C J O'neill and Jason A Bennett and Michael Humphrey and Brian Henry and Malcolm Rowland and Geoff Warhurst},
  journal={British journal of pharmacology},
  year={2002},
  volume={135 8},
  pages={2038-46}
}
1. Intestinal xenobiotic transporters are a significant barrier to the absorption of many orally administered drugs. P-glycoprotein (PGP) is the best known, but several others, including members of the multidrug resistance-associated protein (MRP) family, are also expressed. Definitive information on their precise effect on intestinal drug permeability is scarce due to a lack of specific inhibitors and the difficulty of studying non-PGP activity in the presence of high PGP expression. 2. We… CONTINUE READING

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