Resolution of Mephenytoin and Some Chiral Barbiturates into Enantiomers by Reversed Phase High Performance Liquid Chromatography via β-Cyclodextrin Inclusion Complexes

@article{Sybilska1986ResolutionOM,
  title={Resolution of Mephenytoin and Some Chiral Barbiturates into Enantiomers by Reversed Phase High Performance Liquid Chromatography via $\beta$-Cyclodextrin Inclusion Complexes},
  author={D. Sybilska and J. Żukowski and J. Bojarşki},
  journal={Journal of Liquid Chromatography \& Related Technologies},
  year={1986},
  volume={9},
  pages={591-606}
}
Abstract β-Cyclodextrin as the chiral mobile phase component was used for resolution of mephenytoin and some barbiturates (antidepressant drugs) into enantiomers on LiChrosorb RP 18 column. The effects of β-cyclodextrin concentration on the capacity factors were investigated and the stability constants as well as capacity factors of β-cyclodextrin complexes were calculated. It has been found that β-cyclodextrin complexation results in a distinct enantioselectivity in the case of mephenytoin and… Expand
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