Resolution of Holliday intermediates in recombination and DNA repair: indirect suppression of ruvA, ruvB, and ruvC mutations.

@article{Mandal1993ResolutionOH,
  title={Resolution of Holliday intermediates in recombination and DNA repair: indirect suppression of ruvA, ruvB, and ruvC mutations.},
  author={T N Mandal and Akeel A. Mahdi and Gary J. Sharples and R. G. Lloyd},
  journal={Journal of bacteriology},
  year={1993},
  volume={175 14},
  pages={4325-34}
}
The ruvA, ruvB, and ruvC genes of Escherichia coli provide activities that catalyze branch migration and resolution of Holliday junction intermediates in recombination. Mutation of any one of these genes interferes with recombination and reduces the ability of the cell to repair damage to DNA. A suppressor of ruv mutations was identified on the basis of its ability to restore resistance to mitomycin and UV light and to allow normal levels of recombination in a recBC sbcBC strain carrying a Tn10… CONTINUE READING

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