Resolution of Concentration–Response Differences in Onset of Effect Between Subcutaneous and Oral Sumatriptan

  title={Resolution of Concentration–Response Differences in Onset of Effect Between Subcutaneous and Oral Sumatriptan},
  author={Edda Freidank-Mueschenborn and Anthony W Fox},
  journal={Headache: The Journal of Head and Face Pain},
Objective.—To investigate whether the concentration–response relationships for onset of effect of oral and subcutaneous (s.c.) sumatriptan differ, and if so, then to explore whether a single model for the onset of effect can nonetheless be found for multiple dose sizes and both routes of administration. 
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Why pharmacokinetic differences among oral triptans have little clinical importance: a comment
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Although migraines can be highly disruptive to daily life, effective behavioral and drug treatments can prevent attacks or relieve symptoms and clinicians should exclude secondary causes of headache.
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