Resolution enhancement of suspended microchannel resonators for weighing of biomolecular complexes in solution.

@article{Modena2014ResolutionEO,
  title={Resolution enhancement of suspended microchannel resonators for weighing of biomolecular complexes in solution.},
  author={Mario M. Modena and Yu Wang and D Riedel and Thomas P. Burg},
  journal={Lab on a chip},
  year={2014},
  volume={14 2},
  pages={342-50}
}
We introduce the use of correlation analysis to extend the dynamic range of suspended micro- and nanochannel resonator (SMR/SNR) mass sensors by over five orders of magnitude. This method can analyze populations of particles flowing through an embedded channel micromechanical resonator, even when the individual particle masses are far below the noise floor. To characterize the method, we measured the mass of polystyrene nanoparticles with 300 zg resolution. As an application, we monitored the… CONTINUE READING
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