Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

  title={Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow},
  author={R. Hardy and C. Carmack and S. Shinton and J. Kemp and K. Hayakawa},
  journal={The Journal of Experimental Medicine},
  pages={1213 - 1225}
  • R. Hardy, C. Carmack, +2 authors K. Hayakawa
  • Published 1991
  • Biology, Medicine
  • The Journal of Experimental Medicine
  • We have resolved B220+ IgM- B-lineage cells in mouse bone marrow into four fractions based on differential cell surface expression of determinants recognized by S7 (leukosialin, CD43), BP-1, and 30F1 (heat stable antigen). Functional differences among these fractions can be correlated with Ig gene rearrangement status. The largest fraction, lacking S7, consists of pre-B cells whereas the others, expressing S7, include B lineage cells before pre-B. These S7+ fractions, provisionally termed Fr. A… CONTINUE READING
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