Resolution-adapted recombination of structural features significantly improves sampling in restraint-guided structure calculation


Recent work has shown that NMR structures can be determined by integrating sparse NMR data with structure prediction methods such as Rosetta. The experimental data serve to guide the search for the lowest energy state towards the deep minimum at the native state which is frequently missed in Rosetta de novo structure calculations. However, as the protein… (More)


9 Figures and Tables