Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction.

@article{Verma2003ResistinPE,
  title={Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction.},
  author={Subodh Verma and Shu-hong Li and Chao-Hung Wang and Paul W. M. Fedak and R. K.-Y. Li and Richard D. Weisel and Donald A. G. Mickle},
  journal={Circulation},
  year={2003},
  volume={108 6},
  pages={736-40}
}
BACKGROUND Adipocyte-derived hormones may represent a mechanism linking insulin resistance to cardiovascular disease. In the present study, we evaluated the direct effects of resistin, a novel adipocyte-derived hormone, on endothelial activation. METHODS AND RESULTS Endothelial cells (ECs) were incubated with human recombinant resistin (10 to 100 ng/ML, 24 hours), and endothelin-1 (ET-1) release, ET-1 mRNA expression, and nitric oxide (NO) production were assessed. Transient transfection… CONTINUE READING
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