Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.

@article{Kushiyama2005ResistinlikeMB,
  title={Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.},
  author={Akifumi Kushiyama and Nobuhiro Shojima and Takehide Ogihara and Kouichi Inukai and Hideyuki Sakoda and Midori Fujishiro and Yasushi Fukushima and Motonobu Anai and Hiraku Ono and Nanao Horike and Amelia Y I Viana and Yasunobu Uchijima and Koichi Nishiyama and Tatsuo Shimosawa and Toshiro Fujita and Hideki Katagiri and Yoshitomo Oka and Hiroki Kurihara and Tomoichiro Asano},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 51},
  pages={42016-25}
}
Resistin and resistin-like molecules (RELMs) are a family of proteins reportedly related to insulin resistance and inflammation. Because the serum concentration and intestinal expression level of RELMbeta were elevated in insulin-resistant rodent models, in this study we investigated the effect of RELMbeta on insulin signaling and metabolism using transgenic mice and primary cultured hepatocytes. First, transgenic mice with hepatic RELMbeta overexpression were shown to exhibit significant… CONTINUE READING

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