Resistin is stored in neutrophil granules being released upon challenge with inflammatory stimuli.

@article{Bostrm2009ResistinIS,
  title={Resistin is stored in neutrophil granules being released upon challenge with inflammatory stimuli.},
  author={Elisabeth A Bostr{\"o}m and Andrej Tarkowski and Maria Bokarewa},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1793 12},
  pages={1894-900}
}
We have recently shown that resistin is a key mediator of arthritis accumulating in the inflamed joints and exerting its pro-inflammatory properties independently of TNFalpha. Here we evaluate neutrophils as a cellular source of resistin. Human neutrophils were subjected to subcellular fractionation where the presence of resistin was assessed using western blot, ELISA, and mass spectrometry. Presence of resistin on the neutrophil surface was visualized by flow cytometry. More than 95% of the… CONTINUE READING

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References

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Showing 1-10 of 31 references

Resistin

  • M. Bokarewa, I. Nagaev, L. Dahlberg, U. Smith, A. Tarkowski
  • an adipokine with potent proinflammatory…
  • 2005
Highly Influential
6 Excerpts

Eitzen , Control of granule exocytosis in neutrophils

  • G. P. Lacy
  • Front . Biosci .
  • 2008

McTernan, The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes

  • C. M. Kusminski, N. F. da Silva, +4 authors P.G.S. Kumar
  • J. Clin. Endocrinol. Metab
  • 2007
1 Excerpt

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