Resistin induces insulin resistance by both AMPK-dependent and AMPK-independent mechanisms in HepG2 cells

@article{Luo2009ResistinII,
  title={Resistin induces insulin resistance by both AMPK-dependent and AMPK-independent mechanisms in HepG2 cells},
  author={Zhaofan Luo and Ying Chun Zhang and Fangping Li and Juan He and Helin Ding and Li Yan and Hua Cheng},
  journal={Endocrine},
  year={2009},
  volume={36},
  pages={60-69}
}
Resistin is a 12.5-KDa cysteine-rich peptide that has been implicated in the impairment of glucose homeostasis via the AMP-activated protein kinase (AMPK) pathway in a rodent model. However, the role resistin plays in humans is controversial. This study investigated the effect of resistin on glucose metabolism and insulin signaling using human recombinant resistin and small interfering RNA (siRNA) against AMPKα2 to treat the human liver HepG2 cells. The mRNA of key genes involved in glucose… CONTINUE READING
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