Resistin, central obesity, and type 2 diabetes

  title={Resistin, central obesity, and type 2 diabetes},
  author={Claire L. McTernan and P. G. McTernan and Alison L. Harte and PL Levick and Ah Barnett and S. Kumar},
  journal={The Lancet},

Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice.

Mice generated that lack adipocyte-derived mouse resistin but produce human resistin in a pattern similar to that found in humans, i.e., in macrophages, develop accelerated white adipose tissue inflammation and contribute to insulin resistance.

Over expression of resistin in adipose tissue of the obese induces insulin resistance.

Increased SAT resistin mRNA expression probably leads to inducing insulin resistance and thus may be associated with obesity-related disorders in postmenopausal obese women.

Resistin: an adipocyte‐derived hormone. Has it a role in diabetes and obesity?

The purpose of this review is to summarize the experimental findings to date and to discuss the extent to which the original hypotheses relating to resistin have been confirmed or questioned.

Resistin- and Obesity-associated metabolic diseases.

  • M. Lazar
  • Biology, Medicine
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2007
Given the emerging interrelationship between inflammation and metabolic disease, hyperresistinemia may be a biomarker, and/or a mediator, of metabolic and inflammatory diseases in humans as well as in rodents.

The current biology of resistin

This review will summarize the current understanding of resistin and will attempt to provide a framework for future study of its role in rodent and human physiology.

Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease?

Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk, and an increase in the plasma levels of these mediators may provide a novel mechanistic link between obesity and its vascular complications.

Resistin mRNA levels are downregulated by estrogen in vivo and in vitro

Metabolic effects associated with adipose tissue distribution.

This review presents an overview of the adipose tissue secreted proteins role and their regulation in the context of abdominal obesity and the adverse metabolic consequences.

Resistin Gene Expression in Visceral Adipose Tissue of Postmenopausal Women and its Association with Insulin Resistance

The VAT resistin mRNA expression in postmenopausal obese women is associated to insulin resistance.

Roles of adipocyte derived hormone adiponectin and resistin in insulin resistance of type 2 diabetes.

Plasma adiponectin and resistin are associated with the disorder of metabolism of glucose and lipid in diabetes and the relationship between these hormone and insulin sensitivity suggests that they may take part in the development of insulin resistance of type 2 diabetes.



The hormone resistin links obesity to diabetes

It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.

Relationship of Generalized and Regional Adiposity to Insulin Sensitivity in Men With NIDDM

It is concluded that NIDDM patients do not have excess intraperitoneal fat, but that their fat distribution favors more truncal and less peripheral subcutaneousFat, and for each level of total and regional adiposity, NIDs patients have a heightened state of insulin resistance.

Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden.

The relation between the ratio of waist to hip circumference and the end points of myocardial infarction, angina pectoris, stroke, and death was stronger than for any other anthropometric variable studied.

A Cysteine-rich Adipose Tissue-specific Secretory Factor Inhibits Adipocyte Differentiation*

The regulated expression pattern suggesting this factor as an adipose sensor for the nutritional state of the animals and the inhibitory effect on adipocyte differentiation implicate its function as a feedback regulator of adipogenesis.

Increased endothelin‐1 and decreased adrenomedullin gene expression in the stenotic tissue of congenital pelvi‐ureteric junction obstruction in children

Objectives To test the hypothesis that the gene expression of endothelin‐1 and adrenomedullin may be altered in stenotic tissues of patients with congenital hydronephrosis caused by pelvi‐ureteric