Resistant hepatocytes as early changes in liver induced by polycyclic aromatic hydrocarbons.

@article{Tsuda1980ResistantHA,
  title={Resistant hepatocytes as early changes in liver induced by polycyclic aromatic hydrocarbons.},
  author={Hiroyuki Tsuda and Emmanuel Farber},
  journal={International journal of cancer},
  year={1980},
  volume={25 1},
  pages={137-9}
}
Induction of putative preneoplastic hepatocytes which are resistant to cytotoxic effect of 2-acetylaminofluorene (2-AAF) by five carcinogenic polycyclic aromatic hydrocarbons (PAH) was tested using gamma-glutamyl transpeptidase (gamma-GT) as a histochemical marker enzyme. Benzo (a) pyrene [B(a)P], 7,12-dimethylbenz(a) anthracene (7,12-DMBA), 3-methylcholanthrene (3-MC), dibenz (a,h)-anthracene [DB(a, h)A] and benzo (a) anthracene [B(a)A] were given 12 h after partial hepatectomy (PH) followed… CONTINUE READING