Resistant depressions.

  title={Resistant depressions.},
  author={G. Stranieri},
  journal={Psychiatria Danubina},
  volume={26 Suppl 1},
The concept of Resistant Depression was introduced for the first time in 1974 by Leiman. Despite the numerous studies in this regard, it was not possible to give a precise definition of this problem and to identify a safe etiology. This work aims to contribute through a literature review and exposure of two clinical cases, to better define and analyze this phenomenon by assuming the possible therapeutic strategies for patients with resistant depression.