Resistance to tumor necrosis factor induced apoptosis in vitro correlates with high metastatic capacity of cells in vivo.

@article{Korobko1999ResistanceTT,
  title={Resistance to tumor necrosis factor induced apoptosis in vitro correlates with high metastatic capacity of cells in vivo.},
  author={Elena V. Korobko and L P Saschenko and E B Prockhorchouk and Igor V. Korobko and Nikolai V. Gnuchev and Sergei L. Kiselev},
  journal={Immunology letters},
  year={1999},
  volume={67 2},
  pages={71-6}
}
TNF is one of the cytokines secreted by the cells of the immune system. Our data demonstrate that those cell lines lacking capability to form metastatic tumors in vivo are susceptible to TNF induced apoptosis in vitro. However, cell lines with high metastatic potential are resistant to TNF in vitro. Furthermore, the same cell lines were resistant to cytolytic action of other cytotoxic proteins secreted by LAK cells. Our data showed that TNF resistance in vitro correlates with the increased… CONTINUE READING

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