Resistance to trophic neurite outgrowth of sensory neurons exposed to insulin.

@article{Singh2012ResistanceTT,
  title={Resistance to trophic neurite outgrowth of sensory neurons exposed to insulin.},
  author={Bhagat Phool Singh and Yongqin Xu and Todd McLaughlin and Vandana Singh and J Alfredo Mart{\'i}nez and Anand P. Krishnan and Douglas W Zochodne},
  journal={Journal of neurochemistry},
  year={2012},
  volume={121 2},
  pages={263-76}
}
Insulin offers trophic support through receptors expressed widely on peripheral neurons. In this work, we studied whether peripheral sensory neurons demonstrate resistance to its trophic properties, a property relevant during type 2 diabetes mellitus or following supraphysiological therapy. Insulin receptors were not only localized to neuronal membranes and cytoplasm but also had a unique, previously unrecognized localization to neuronal nuclei. We confirmed that nanomolar doses increased… CONTINUE READING