Resistance to rifampicin: a review

@article{Goldstein2014ResistanceTR,
  title={Resistance to rifampicin: a review},
  author={Beth P Goldstein},
  journal={The Journal of Antibiotics},
  year={2014},
  volume={67},
  pages={625-630}
}
Resistance to rifampicin (RIF) is a broad subject covering not just the mechanism of clinical resistance, nearly always due to a genetic change in the β subunit of bacterial RNA polymerase (RNAP), but also how studies of resistant polymerases have helped us understand the structure of the enzyme, the intricacies of the transcription process and its role in complex physiological pathways. This review can only scratch the surface of these phenomena. The identification, in strains of Escherichia… CONTINUE READING

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