Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection.

Abstract

Inhibitors that target the retroviral enzyme reverse transcriptase (RT) have played an indispensable role in the treatment and prevention of HIV-1 infection. They can be grouped into two distinct therapeutic groups, namely the nucleoside and nucleotide RT inhibitors (NRTIs), and the non-nucleoside RT inhibitors (NNRTIs). NRTIs form the backbones of most… (More)
DOI: 10.2217/fmb.15.106

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