Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen).

  title={Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen).},
  author={Kevin E. Brown and J R Hibbs and Giorgio Gallinella and Steven M. Anderson and Elizabeth Lehman and P Mccarthy and Neal S. Young},
  journal={The New England journal of medicine},
  volume={330 17},
BACKGROUND The presence of a specific cellular receptor is thought to be necessary for susceptibility to viral infection. The erythrocyte P antigen is the cellular receptor for parvovirus B19. We hypothesized that the rare persons with the p phenotype, whose erythrocytes do not have this receptor, would be naturally resistant to B19 infection, which causes erythema infectiosum. METHODS Blood samples were collected from two populations in cross-sectional studies. We determined the P antigen… CONTINUE READING
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