Resistance to paclitaxel is proportional to cellular total antioxidant capacity.

  title={Resistance to paclitaxel is proportional to cellular total antioxidant capacity.},
  author={Balakrishnan Ramanathan and K R Jan and C Chen and T C Hour and H Yu and Yeong Shiau Pu},
  journal={Cancer research},
  volume={65 18},
Paclitaxel, one of the most commonly prescribed chemotherapeutic agents, is active against a wide spectrum of human cancer. The mechanism of its cytotoxicity, however, remains controversial. Our results indicate that paclitaxel treatment increases levels of superoxide, hydrogen peroxide, nitric oxide (NO), oxidative DNA adducts, G2-M arrest, and cells with fragmented nuclei. Antioxidants pyruvate and selenium, the NO synthase inhibitor N(omega)-nitro-L-arginine methyl ester, and the NO… CONTINUE READING


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Perturbation of actin dynamics induces NF-nB activation in myelomonocytic cells via a NADPH oxidasedependent pathway

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