Resistance to nonribosomal peptide antibiotics mediated by D-stereospecific peptidases.

Abstract

Nonribosomal peptide antibiotics, including polymyxin, vancomycin, and teixobactin, most of which contain D-amino acids, are highly effective against multidrug-resistant bacteria. However, overusing antibiotics while ignoring the risk of resistance arising has inexorably led to widespread emergence of resistant bacteria. Therefore, elucidation of the… (More)
DOI: 10.1038/s41589-018-0009-4

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