Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection?

@article{Baker2000ResistanceTM,
  title={Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection?},
  author={John E Baker and Eugene A Konorev and Garrett Gross and William M. Chilian and Howard J. Jacob},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={278 4},
  pages={H1395-400}
}
There is a need to develop new and more consistent animal models of cardioprotection. Traditionally, outbred dogs, rabbits, and rats have been studied. We determined resistance to ischemia in isolated hearts from inbred strains of rats. Hearts from inbred rats: SS/Mcw (Dahl S, Dahl salt-sensitive), DA/Hsd (Dark Agouti), LEW/Hsd (Lewis), and BN/SsN/Mcw (Brown Norway); and from an outbred rat: Hsd:WIST (Wistar) were subjected to 27 min of global, no-flow ischemia, followed by 3 h of reperfusion… CONTINUE READING

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