Resistance to murine hepatitis virus strain 3 is dependent on production of nitric oxide.

@article{Pope1998ResistanceTM,
  title={Resistance to murine hepatitis virus strain 3 is dependent on production of nitric oxide.},
  author={M Pope and Philip A. Marsden and Edward H. Cole and Stephen L Sloan and Laisum S Fung and Xiaoyang Wan and Jin Wen Ding and Julian L. Leibowitz and Melville J Phillips and Gary A. Levy},
  journal={Journal of virology},
  year={1998},
  volume={72 9},
  pages={7084-90}
}
The strain-specific spectrum of liver disease following murine hepatitis virus type 3 (MHV-3) infection is dependent on inflammatory mediators released by macrophages. Production of nitric oxide (NO) by macrophages has been implicated in resistance to a number of viruses, including ectromelia virus, vaccinia virus, and herpes simplex virus type 1. This study was undertaken to define the role of NO in MHV-3 infection. Gamma interferon-induced production of NO inhibited growth of MHV-3 in a… CONTINUE READING
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