Resistance to liver fluke infection in the natural sheep host is correlated with a type-1 cytokine response.

@article{Pleasance2011ResistanceTL,
  title={Resistance to liver fluke infection in the natural sheep host is correlated with a type-1 cytokine response.},
  author={Jill Pleasance and E. Wiedosari and Herman W. Raadsma and Els N T Meeusen and David Piedrafita},
  journal={Parasite immunology},
  year={2011},
  volume={33 9},
  pages={495-505}
}
Indonesian thin-tail (ITT) sheep can resist infection with Fasciola gigantica but not F. hepatica and presents an ideal model to investigate the mechanisms of liver fluke resistance in a natural host. This study examines the local and systemic immune responses of sheep during Fasciola infection and demonstrates that different anatomical tissues display distinct cytokine profiles consistent with liver fluke migration. The study also reveals a significant difference in the cytokine and antibody… CONTINUE READING