Resistance to indomethacin-induced down-regulation of hepatic cytochrome P450 enzymes in the mice with non-functional Toll-like receptor 4.

@article{Masubuchi2003ResistanceTI,
  title={Resistance to indomethacin-induced down-regulation of hepatic cytochrome P450 enzymes in the mice with non-functional Toll-like receptor 4.},
  author={Yasuhiro Masubuchi and Toshiharu Horie},
  journal={Journal of hepatology},
  year={2003},
  volume={39 3},
  pages={
          349-56
        }
}
BACKGROUND/AIMS Repetitive indomethacin administration induces down-regulation of hepatic cytochrome P450 (CYP) enzymes. We tested the hypothesis that an increase in intestinal permeability by indomethacin-induced intestinal injury leads to entry of bacterial endotoxin and reaching into liver via the portal vein, resulting in down-regulations of CYPs. METHODS C3H/HeJ mice, which are resistant to endotoxin, have a mutation in Toll-like receptor 4 gene. The sensitivity to indomethacin-induced… CONTINUE READING
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