Resistance to human immunodeficiency virus type 1 in vitro as a surrogate of vaccine-induced protective immunity.

@article{Castillo2000ResistanceTH,
  title={Resistance to human immunodeficiency virus type 1 in vitro as a surrogate of vaccine-induced protective immunity.},
  author={Renan C. Castillo and Silvio Arango-Jaramillo and Rohan John and Kent J. Weinhold and Phyllis J Kanki and Lucy M. Carruth and David R. Schwartz},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={181 3},
  pages={897-903}
}
An in vitro assay developed as a correlate of vaccine-induced protection from human immunodeficiency virus (HIV) was validated in populations with relative resistance to HIV-1 as well as in HIV vaccine recipients. Cultures of peripheral blood mononuclear cells (PBMC) were challenged with 10 TCID50 of HIV-1MN or HIV-1BaL, titered in PBMC from normal controls (n=57). PBMC from HIV-1-infected persons with low viremia (n=17), exposed uninfected persons (n=23), and HIV-2-infected Senegalese… CONTINUE READING
4 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…