Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency.

@article{Zhang2010ResistanceTH,
  title={Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency.},
  author={Dongyan Zhang and Jennifer L. Christianson and Z X Liu and Liqun Tian and Cheol Soo Choi and Susanne Neschen and Jianying Dong and Philip A. Wood and Gerald I Shulman},
  journal={Cell metabolism},
  year={2010},
  volume={11 5},
  pages={402-11}
}
Mitochondrial fatty acid oxidation provides an important energy source for cellular metabolism, and decreased mitochondrial fatty acid oxidation has been implicated in the pathogenesis of type 2 diabetes. Paradoxically, mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very long-chain acyl-CoA dehydrogenase (VLCAD), were protected from high-fat diet-induced obesity and liver and muscle insulin resistance. This was associated with reduced intracellular… CONTINUE READING

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