Resistance to experimental autoimmune thyroiditis induced by physiologic manipulation of thyroglobulin level.

@article{Lewis1987ResistanceTE,
  title={Resistance to experimental autoimmune thyroiditis induced by physiologic manipulation of thyroglobulin level.},
  author={Michael T. Lewis and Alvaro A. Giraldo and Yi-chi M. Kong},
  journal={Clinical immunology and immunopathology},
  year={1987},
  volume={45 1},
  pages={92-104}
}
The role of circulatory mouse thyroglobulin (MTg) level in activating mechanisms suppressive to induction of experimental autoimmune thyroiditis (EAT) was studied by two regimens to strengthen normal maintenance of self-tolerance in genetically susceptible mice. One was to administer graded doses of exogenous MTg either 7 days apart or daily for 10 days and then challenge the animals with MTg + LPS. The other was to infuse TSH via an osmotic pump for 7 days. The steady TSH infusion for 7 days… CONTINUE READING

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