Resistance to experimental autoimmune thyroiditis: L3T4+ cells as mediators of both thyroglobulin-activated and TSH-induced suppression.

@article{Kong1989ResistanceTE,
  title={Resistance to experimental autoimmune thyroiditis: L3T4+ cells as mediators of both thyroglobulin-activated and TSH-induced suppression.},
  author={Yi-chi M. Kong and Alvaro A. Giraldo and Herman Waldmann and Stephen Paul Cobbold and Brian E. Fuller},
  journal={Clinical immunology and immunopathology},
  year={1989},
  volume={51 1},
  pages={38-54}
}
Mechanisms suppressive to induction of murine experimental autoimmune thyroiditis (EAT) can be activated by pretreatment with tolerogenic doses of mouse thyroglobulin (MTg) or prior TSH infusion to raise circulatory MTg levels. MTg-activated suppressor T cells (Ts), shown earlier to be Thy-1+ and probably I-J+, were further characterized by in vivo administration of paired rat monoclonal antibodies to distinct epitopes on the L3T4 or Lyt-2 molecule, either on the day of, or subsequent to… CONTINUE READING

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