Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice.

Abstract

Endotoxin shock is the result of activation of the immune system by endotoxin/LPS, a component of Gram-negative bacteria. CD14, a GPI-anchored glycoprotein expressed strongly by monocyte/macrophages, is one of several receptors for endotoxin/LPS. The role of CD14 in bacterial-induced and LPS-induced shock was tested in CD14-deficient mice produced by gene… (More)

Topics

  • Presentations referencing similar topics