Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr.

@article{Lowell1998ResistanceTE,
  title={Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr.},
  author={Clifford A Lowell and Giorgio Berton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 13},
  pages={7580-4}
}
Signal transduction through the leukocyte integrins is required for the processes of firm adhesion, activation, and chemotaxis of neutrophils during inflammatory reactions. Neutrophils isolated from knockout mice that are deficient in the expression of p59/61(hck) (Hck) and p58(c-fgr) (Fgr), members of the Src-family of protein tyrosine kinases, have been shown to be defective in adhesion mediated activation. Cells from these animals have impaired induction of respiratory burst and granule… CONTINUE READING

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Lowell and Berton Proc

J. W. Conlan, North, 52 R.J.J.LeukocyteBiol., 130–132. 7584 Immunology
Natl. Acad. Sci. USA 95 • 1998
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