Resistance to endocrine therapy in breast cancer

  title={Resistance to endocrine therapy in breast cancer},
  author={Junichi Kurebayashi},
  journal={Cancer Chemotherapy and Pharmacology},
Endocrine therapy is the treatment of choice for patients with breast cancer expressing estrogen receptor (ER) and/or progesterone receptor. The efficacy of endocrine therapy is well established in the prevention, adjuvant and metastatic settings. However, either de novo or acquired resistance is frequently observed. Much effort has been made to elucidate the mechanisms of action underlying resistance to endocrine therapy in breast cancer, and several possible explanations have been suggested… CONTINUE READING