Resistance to drug by different isolates Trypanosoma evansi in China.

@article{Zhou2004ResistanceTD,
  title={Resistance to drug by different isolates Trypanosoma evansi in China.},
  author={Jinlin Zhou and Jie Shen and Dangjin Liao and Yongzhi Zhou and Jiaojiao Lin},
  journal={Acta tropica},
  year={2004},
  volume={90 3},
  pages={
          271-5
        }
}
In order to understand drug resistance in Chinese Trypanosoma evansi isolates, the in vitro growth inhibition test was carried out to detect the sensitivities to suramin and antrycide of 12 T. evansi isolates. For suramin, 50% inhibitory concentrations (IC(50)) ranged from 0.041 to 0.752 microg/ml; for antrycide, the IC(50) values ranged from 0.00151 to 0.06694 microg/ml. In vivo experiments in mice with selected isolates showed that the isolate most resistant to suramin was not cured at a… CONTINUE READING
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