Resistance to direct antiviral agents in patients with hepatitis C virus infection.

  title={Resistance to direct antiviral agents in patients with hepatitis C virus infection.},
  author={Christoph Sarrazin and Stefan Zeuzem},
  volume={138 2},
Chronic hepatitis C virus (HCV) infection is one of the major causes of cirrhosis, hepatocellular carcinoma, and liver failure that leads to transplantation. The current standard treatment, a combination of pegylated interferon alfa and ribavirin, eradicates the virus in only about 50% of patients. Directly acting antiviral (DAA) agents, which inhibit HCV replication, are in phase 1, 2, and 3 trials; these include reagents that target the nonstructural (NS)3 protease, the NS5A protein, the RNA… CONTINUE READING
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