Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells.

@article{Aebi1997ResistanceTC,
  title={Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells.},
  author={Suzanne Aebi and Daniel Fink and Robert Harry Gordon and Hark Kyun Kim and Huili Zheng and J. Lynn Fink and Stephen B. Howell},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1997},
  volume={3 10},
  pages={
          1763-7
        }
}
Loss of DNA mismatch repair is a common finding in many types of sporadic human cancers as well as in tumors arising in patients with hereditary nonpolyposis colon cancer. The effect of the loss of DNA mismatch repair activity on sensitivity to a panel of commonly used chemotherapeutic agents was tested using one pair of cell lines proficient or deficient in mismatch repair due to loss of hMSH2 function and another due to loss of hMLH1 function. 6-Thioguanine and N-methyl-N'-nitro-N… CONTINUE READING

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