Resistance to bovine respiratory syncytial virus (BRSV) induced in calves by a recombinant bovine herpesvirus-1 expressing the attachment glycoprotein of BRSV.

@article{Taylor1998ResistanceTB,
  title={Resistance to bovine respiratory syncytial virus (BRSV) induced in calves by a recombinant bovine herpesvirus-1 expressing the attachment glycoprotein of BRSV.},
  author={Geraldine Taylor and Frans A. M. Rijsewijk and Lewis H. Thomas and Sara G. Wyld and Ruth M. Gaddum and Roy S Cook and William Ivan Morrison and Evert J. Hensen and J T van Oirschot and G Keil},
  journal={The Journal of general virology},
  year={1998},
  volume={79 ( Pt 7)},
  pages={1759-67}
}
The ability of a bovine herpesvirus-1 (BHV-1) recombinant expressing the G protein of bovine respiratory syncytial virus (BRSV) to protect against BRSV infection was examined in calves. A synthetic G gene was inserted behind the gE promoter of BHV-1 to give a gE-negative, BHV-1/G recombinant. Gnotobiotic calves, vaccinated intranasally and intratracheally with BHV-1/G were challenged 6 weeks later with the Snook strain of BRSV. As controls, calves were vaccinated with a gE-negative mutant of… CONTINUE READING
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