Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins.

@article{Wang1997ResistanceTA,
  title={Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins.},
  author={Ping Wang and Chun Seok Lee and R. A. L. Bayoumi and Abdoulaye A. Djimd{\'e} and Ogobara K. Doumbo and G{\"o}te Swedberg and Le Duc Dao and Hassan M Mshinda and Marcel Tanner and William M. Watkins and P. F. Sims and J. E. Hyde},
  journal={Molecular and biochemical parasitology},
  year={1997},
  volume={89 2},
  pages={161-77}
}
Resistance of Plasmodium falciparum to antifolate chemotherapy is a significant problem where combinations such as Fansidar (pyrimethamine-sulfadoxine; PYR-SDX) are used in the treatment of chloroquine-resistant malaria. Antifolate resistance has been associated with variant sequences of dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS), the targets of PYR and SDX respectively. However, while the nature and distribution of mutations in the dhfr gene are well established, this… CONTINUE READING
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