Resistance to antibiotics mediated by target alterations.

  title={Resistance to antibiotics mediated by target alterations.},
  author={Brian G. Spratt},
  volume={264 5157},
  • B. Spratt
  • Published 15 April 1994
  • Biology
  • Science
The development of resistance to antibiotics by reductions in the affinities of their enzymatic targets occurs most rapidly for antibiotics that inactivate a single target and that are not analogs of substrate. In these cases of resistance (for example, resistance to rifampicin), numerous single amino acid substitutions may provide large decreases in the affinity of the target for the antibiotic, leading to clinically significant levels of resistance. Resistance due to target alterations should… 

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