Resistance to and synthesis of the antibiotic mupirocin

  title={Resistance to and synthesis of the antibiotic mupirocin},
  author={Christopher M. Thomas and J. Daniel Hothersall and Christine L Willis and Thomas J Simpson},
  journal={Nature Reviews Microbiology},
Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out… CONTINUE READING
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