Resistance to and synthesis of the antibiotic mupirocin

@article{Thomas2010ResistanceTA,
  title={Resistance to and synthesis of the antibiotic mupirocin},
  author={Christopher M. Thomas and J. Daniel Hothersall and Christine L Willis and Thomas J Simpson},
  journal={Nature Reviews Microbiology},
  year={2010},
  volume={8},
  pages={281-289}
}
Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out… CONTINUE READING
39 Citations
81 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 81 references

Cost-efficacy analysis of topical ozonized oil versus mupirocin cream in the treatment of impetigo

  • K. Alfonso, M. Collazo, M. Fernandez, C. Ballagas
  • Lat. Am. J. Pharm. 27,
  • 2008

Similar Papers

Loading similar papers…