Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.

@article{Kelly1994ResistanceTA,
  title={Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.},
  author={Stephen L Kelly and David Christopher Lamb and Mark Taylor and Andy Corran and Brian C Baldwin and William G. Powderly},
  journal={FEMS microbiology letters},
  year={1994},
  volume={122 1-2},
  pages={39-42}
}
Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol delta 8-->7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1. 

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