Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways

@inproceedings{Dijk2013ResistanceTT,
  title={Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways},
  author={Marie van Dijk and Anna Halpin-McCormick and Tamas Sessler and Afshin Samali and Eva Szegezdi},
  booktitle={Cell Death and Disease},
  year={2013}
}
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine and a selective inducer of apoptosis in a range of tumour cells, but not in normal, untransformed cells. A large number of chemotherapeutics as well as biological agents are being tested for their potential to sensitise resistant tumour cells to TRAIL as a means to broaden the range of tumours treatable with TRAIL. However, because of the incomplete understanding of the mechanism(s) underlying TRAIL resistance in non… CONTINUE READING

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