Resistance to Sulphadiazine and ‘Paludrine’ in the Malaria Parasite of the Fowl (p. Gallinaceum)

  title={Resistance to Sulphadiazine and ‘Paludrine’ in the Malaria Parasite of the Fowl (p. Gallinaceum)},
  author={Ann Bishop and Elspeth W. McConnachie},
Acquired Resistance to Sulphadiazine 

The inhibition by p-aminobenzoic acid of the development of paludrine-resistance as produced by sulphonamides in plasmodium gallinaceum

A strain of Plasmodium gallinaceum has been treated for 10 weeks with sulphadiazine (5 mg./20 g.) in the presence of p-aminobenzoic acid in doses (0·5 mg./ 20 g.) inhibiting the sulphadiazine. No

Cross-resistance between sulphanilamide and paludrine (proguanil) in a strain of Plasmodium gallinaceum resistant to sulphanilamide

The sulphanilamide-resistant strain was resistant to paludrine over the whole range of doses tolerated by the host; it also proved to be resistant to sulphathiazole, sulphapyridine and sulpha-diazine, though the degree of resistance shown was much slighter than to Paludrine.

Pamaquin Resistance in a Strain of Plasmodium gallinaceum and its relationship to Other antimalarial Drugs

A four- to eight-fold increase in resistance to pamaquin has been developed in a strain of Plasmodium gallinaceum in chicks, and an appreciable loss in resistance was observed after it had been maintained in the absence of the drug for a period of 6 months.

Partial Inhibition by Mepacrine of the Development of Sulphonamide Resistance in Plasmodium berghei

It is explored whether the simultaneous administration of mepacrine and a sulphonamide in malaria would result in any change in the pattern of development of resistance of the parasites to either drug.


  • A. F. Crowther
  • Medicine, Biology
    The Journal of pharmacy and pharmacology
  • 1958
There is a high degree of specificity in host‐parasite relationships for, with the exception of Plasmodium vivax which can produce a mild parasitaemia in chimpanzees1, none of the human parasites has yet been transmitted to other animals.

Latent infections in avian malaria in relation to the production of drug-resistance

The failure to obtain resistant strains of malaria by prolonged treatment of latent infections with large amounts of drug, lends support to the theory of the origin of resistant strainsof malaria by the selection of resistant mutants.

Sulphadiazine-resistance in Plasmodium gallinaceum and its relation to other antimalarial compounds

A thirty-two-fold increase in resistance to sulphadiazine has been induced in Plasmodium gallinaceum in chicks by treatment with that drug, and it is not considered probable that cross-resistance between sulphADiazine and paludrine is due to a similar mode of action of these drugs.

Proguanil, the isolation of a metabolite with high antimalarial activity.

The existence of a metabolite, wholly or partly responsible for the antimalarial activity of " Paludrine " [proguanil, N'-p-chlorophenyl-N-isopropyldiguanide (I; R=H)], has been suspected for some

The mode of action of sulphonamides, proguanil and pyrimethamine on Plasmodium gallinaceum.

  • I. Rollo
  • Biology
    British journal of pharmacology and chemotherapy
  • 1955
An attempt is made to fill some of the gaps in knowledge of crossresistance, potentiation, and antagonism between antimalarial drugs, by reviewing and analysing the known facts, in the light of new data.



Acquired Resistance to Paludrine in Plasmodium Gallinaceum

Acquired Resistance and Persistence after Passage through the Mosquito

Drug-resistance in Plasmodium gallinaceum, and the persistence of paludrine-resistance after mosquito transmission

Chickscarrying a latent infection of the normal strain of P. gallinaceum were immune to infection with the paludrine-resistant strain; and conversely chicks carrying a latent infections of the palUDrine- resistant strain were immune with the normal parasite.

Effects of Paludrine and Other Antimalarials

THE facility with which pathogenic protozoa and A bacteria may acquire resistance to therapeutic agents, as a result of non-curative treatment of infections by these pathogens, is of profound

Inhibition of Antimalarial Action of Sulfonamides by p-Amino-benzoic Acid

The effect of p-aminobenzoic acid in inhibiting the action of sulfanilamide against plasmodia is reported, which is thought to be essential to the organism.