Resistance to Rift Valley fever virus in Rattus norvegicus: genetic variability within certain 'inbred' strains.

  title={Resistance to Rift Valley fever virus in Rattus norvegicus: genetic variability within certain 'inbred' strains.},
  author={Mary Ritter and Mich{\`e}le Bouloy and Pierre Vialat and Christian Janzen and Otto Haller and Michael Frese},
  journal={The Journal of general virology},
  volume={81 Pt 11},
Rift Valley fever virus (RVFV) is the causative agent of Rift Valley fever, a widespread disease of domestic animals and humans in sub-Saharan Africa. Laboratory rats have frequently been used as an animal model for studying the pathogenesis of Rift Valley fever. It is shown here that Lewis rats (LEW/mol) are susceptible to infection with RVFV, whereas Wistar-Furth (WF/mol) rats are resistant to RVFV infection. LEW/mol rats developed acute hepatitis and died after infection with RVFV strain… CONTINUE READING
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